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Inactive state stabilized by the ECD and ECL1/3 In the GLP-1RFab7F38 structure, the saddle-like ECD loop S116-E127 covers the ECL1 helical region Q211-S219 that partially occupies the orthosteric ECD-binding site (Fig

Within cholangiocytes (biliary epithelial cells that line the biliary tree) the activation of the SCTR results in increased secretion of Cl , HCO 3 , and H 2 O

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Clinical studies show that B